A comparison of live and inactivated influenza A (H1N1) virus vaccines
Identifieur interne : 000395 ( Istex/Curation ); précédent : 000394; suivant : 000396A comparison of live and inactivated influenza A (H1N1) virus vaccines
Auteurs : A. Clark ; C. W. Potter ; R. Jennings ; J. P. Nicholl ; A. F. Langrick [Royaume-Uni] ; G. C. Schild ; J. M. Wood ; D. A. J. TyrrellSource :
- Journal of Hygiene [ 0022-1724 ] ; 1983-06.
Abstract
Groups of volunteers were immunized with one of three influenza virus vaccines, and the resistance to challenge infection with attenuated influenza A (H1N1) virus was measured 8 months later. The vaccines were aqueous subunit influenza A/USSR/77 (H1N1) vaccine, aqueous subunit influenza B/Hong Kong/73 vaccine, or attenuated influenza virus A (H1N1) vaccine. The B virus vaccine was included as a control to assess the incidence of natural A virus infection during the study period. A proportion of the B virus vaccinees had pre-existing A (H1N1) virus antibody and were used to study the immunity conferred by natural infection to the live virus challenge. The serum antibody responses were measured at 1 and 8 months after immunization. The results showed that all the vaccines induced serum HI antibody in a proportion of the volunteers; however, after 1 month, higher titres of serum antibody were found in volunteers given inactivated A vaccine than in those given live attenuated A virus vaccine. Eight months post-immunization the titres of serum antibody in volunteers given inactivated vaccine had declined significantly, but there were no changes in the antibody titres of those given live virus vaccine. The incidence of infection by the challenge virus at 8 months post-immunization was directly related to the serum antibody titres 1 month post-immunization; no evidence was obtained to suggest that those given live virus vaccine had a more solid immunity than those given inactivated vaccine.
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DOI: 10.1017/S0022172400028990
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A. Clark<affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation><wicri:noCountry code="subField">2RX</wicri:noCountry></affiliation><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation><wicri:noCountry code="subField">2RX</wicri:noCountry></affiliation><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation><wicri:noCountry code="subField">2RX</wicri:noCountry></affiliation><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation><wicri:noCountry code="subField">2RX</wicri:noCountry></affiliation><affiliation><mods:affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</mods:affiliation><wicri:noCountry code="subField">6RB</wicri:noCountry></affiliation><affiliation><mods:affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</mods:affiliation><wicri:noCountry code="subField">6RB</wicri:noCountry></affiliation><affiliation><mods:affiliation>Division of Communicable Diseases, Medical Research Council, Clinical Research Centre, Watford Road, Harrow, HA1 3UJ</mods:affiliation><wicri:noCountry code="subField">3UJ</wicri:noCountry></affiliation>Le document en format XML
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Schild</name><affiliation><mods:affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</mods:affiliation><wicri:noCountry code="subField">6RB</wicri:noCountry></affiliation></author><author><name sortKey="Wood, J M" sort="Wood, J M" uniqKey="Wood J" first="J. M." last="Wood">J. M. Wood</name><affiliation><mods:affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</mods:affiliation><wicri:noCountry code="subField">6RB</wicri:noCountry></affiliation></author><author><name sortKey="Tyrrell, D A J" sort="Tyrrell, D A J" uniqKey="Tyrrell D" first="D. A. J." last="Tyrrell">D. A. J. Tyrrell</name><affiliation><mods:affiliation>Division of Communicable Diseases, Medical Research Council, Clinical Research Centre, Watford Road, Harrow, HA1 3UJ</mods:affiliation><wicri:noCountry code="subField">3UJ</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C6311DC19692F1A134E73B897CFE23C5583EC119</idno><date when="1983" year="1983">1983</date><idno type="doi">10.1017/S0022172400028990</idno><idno type="url">https://api.istex.fr/ark:/67375/6GQ-S4Z2CXGR-4/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000395</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000395</idno><idno type="wicri:Area/Istex/Curation">000395</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">A comparison of live and inactivated influenza A (H1N1) virus vaccines</title><author><name sortKey="Clark, A" sort="Clark, A" uniqKey="Clark A" first="A." last="Clark">A. Clark</name><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation><wicri:noCountry code="subField">2RX</wicri:noCountry></affiliation></author><author><name sortKey="Potter, C W" sort="Potter, C W" uniqKey="Potter C" first="C. W." last="Potter">C. W. Potter</name><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation><wicri:noCountry code="subField">2RX</wicri:noCountry></affiliation></author><author><name sortKey="Jennings, R" sort="Jennings, R" uniqKey="Jennings R" first="R." last="Jennings">R. Jennings</name><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation><wicri:noCountry code="subField">2RX</wicri:noCountry></affiliation></author><author><name sortKey="Nicholl, J P" sort="Nicholl, J P" uniqKey="Nicholl J" first="J. P." last="Nicholl">J. P. Nicholl</name><affiliation><mods:affiliation>Departments of Medical Microbiology, Virology and Community Medicine, University of Sheffield Medical School, Beech Hill Road, Sheffield, 510 2RX</mods:affiliation><wicri:noCountry code="subField">2RX</wicri:noCountry></affiliation></author><author><name sortKey="Langrick, A F" sort="Langrick, A F" uniqKey="Langrick A" first="A. F." last="Langrick">A. F. Langrick</name><affiliation wicri:level="4"><mods:affiliation>Health Centre, University of Birmingham, Birmingham, B15 2TJ</mods:affiliation><orgName type="university">Université de Birmingham</orgName><country>Royaume-Uni</country><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Schild, G C" sort="Schild, G C" uniqKey="Schild G" first="G. C." last="Schild">G. C. Schild</name><affiliation><mods:affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</mods:affiliation><wicri:noCountry code="subField">6RB</wicri:noCountry></affiliation></author><author><name sortKey="Wood, J M" sort="Wood, J M" uniqKey="Wood J" first="J. M." last="Wood">J. M. Wood</name><affiliation><mods:affiliation>Division of Viral Products, National Institute for Biological Standardization and Control, Holly Hill, Hampstead, London, NW3 6RB</mods:affiliation><wicri:noCountry code="subField">6RB</wicri:noCountry></affiliation></author><author><name sortKey="Tyrrell, D A J" sort="Tyrrell, D A J" uniqKey="Tyrrell D" first="D. A. J." last="Tyrrell">D. A. J. Tyrrell</name><affiliation><mods:affiliation>Division of Communicable Diseases, Medical Research Council, Clinical Research Centre, Watford Road, Harrow, HA1 3UJ</mods:affiliation><wicri:noCountry code="subField">3UJ</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Hygiene</title><title level="j" type="abbrev">J. Hyg.</title><idno type="ISSN">0022-1724</idno><imprint><publisher>Cambridge University Press</publisher><pubPlace>Cambridge, UK</pubPlace><date type="published" when="1983-06">1983-06</date><biblScope unit="volume">90</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="361">361</biblScope><biblScope unit="page" to="370">370</biblScope></imprint><idno type="ISSN">0022-1724</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1724</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Groups of volunteers were immunized with one of three influenza virus vaccines, and the resistance to challenge infection with attenuated influenza A (H1N1) virus was measured 8 months later. The vaccines were aqueous subunit influenza A/USSR/77 (H1N1) vaccine, aqueous subunit influenza B/Hong Kong/73 vaccine, or attenuated influenza virus A (H1N1) vaccine. The B virus vaccine was included as a control to assess the incidence of natural A virus infection during the study period. A proportion of the B virus vaccinees had pre-existing A (H1N1) virus antibody and were used to study the immunity conferred by natural infection to the live virus challenge. The serum antibody responses were measured at 1 and 8 months after immunization. The results showed that all the vaccines induced serum HI antibody in a proportion of the volunteers; however, after 1 month, higher titres of serum antibody were found in volunteers given inactivated A vaccine than in those given live attenuated A virus vaccine. Eight months post-immunization the titres of serum antibody in volunteers given inactivated vaccine had declined significantly, but there were no changes in the antibody titres of those given live virus vaccine. The incidence of infection by the challenge virus at 8 months post-immunization was directly related to the serum antibody titres 1 month post-immunization; no evidence was obtained to suggest that those given live virus vaccine had a more solid immunity than those given inactivated vaccine.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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